Philip Lazarus Selected Research

Glucuronosyltransferase (UDP Glucuronosyltransferase)

12/2012	Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility.
2/2011	Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.
3/2010	UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility.
10/2009	Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.
4/2007	The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.
6/2006	Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform.
6/2004	Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer.
8/2003	Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk.

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Philip Lazarus Research Topics

Disease

39	Neoplasms (Cancer) 01/2022 - 07/2002
25	Lung Neoplasms (Lung Cancer) 01/2022 - 04/2003
15	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2006
6	Head and Neck Neoplasms (Head and Neck Cancer) 10/2012 - 12/2003
5	Colorectal Neoplasms (Colorectal Cancer) 10/2015 - 01/2013
4	Carcinogenesis 01/2022 - 08/2008
3	Tobacco Use Disorder (Nicotine Dependence) 03/2021 - 01/2009
3	Inflammation (Inflammations) 01/2021 - 04/2010
3	Hot Flashes 10/2020 - 02/2009
3	Laryngeal Neoplasms (Laryngeal Cancer) 01/2019 - 08/2008
2	Oropharyngeal Neoplasms 01/2022 - 09/2011
2	Mouth Neoplasms (Oral Cancer) 01/2022 - 12/2015
2	Adenocarcinoma of Lung 01/2020 - 08/2010
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019 - 10/2014
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2017 - 06/2004
2	Adenocarcinoma 02/2015 - 10/2014
2	Marijuana Use 01/2014 - 05/2009
2	Colonic Neoplasms (Colon Cancer) 01/2013 - 11/2007
2	Venous Thrombosis (Deep-Vein Thrombosis) 02/2010 - 02/2009
2	Endometrial Neoplasms (Endometrial Cancer) 02/2010 - 02/2009
2	Prostatic Neoplasms (Prostate Cancer) 06/2004 - 12/2003
1	Squamous Cell Carcinoma of Head and Neck 01/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2021
1	Disease Susceptibility (Diathesis) 01/2021
1	Fatigue 10/2020
1	Arthralgia (Joint Pain) 10/2020
1	Obesity 01/2017
1	Small Cell Carcinoma 01/2017
1	Hemochromatosis (Bronze Diabetes) 12/2015
1	Body Weight (Weight, Body) 01/2015
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2014
1	Tongue Neoplasms (Tongue Neoplasm) 01/2014

Drug/Important Bio-Agent (IBA)

11	CarcinogensIBA 01/2020 - 04/2003
11	SmokeIBA 09/2016 - 04/2003
9	exemestane (Aromasin)FDA Link 01/2022 - 02/2010
8	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 12/2012 - 08/2003
7	Estrogen ReceptorsIBA 01/2022 - 10/2007
6	EnzymesIBA 12/2021 - 06/2004
6	ORALIT (ORS)IBA 01/2021 - 12/2003
6	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 07/2002
6	Tamoxifen FDA LinkGeneric 02/2010 - 01/2006
5	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 01/2022 - 06/2006
5	bilirubin uridine-diphosphoglucuronosyl transferase 1A10 (UGT1A10)IBA 06/2014 - 08/2003
4	NitrosaminesIBA 01/2022 - 05/2008
4	Estrogens (Estrogen)FDA Link 12/2021 - 09/2015
4	Biological ProductsIBA 04/2021 - 09/2015
4	Nicotine FDA Link 03/2021 - 01/2004
4	Aromatase InhibitorsIBA 12/2018 - 02/2010
4	Selective Estrogen Receptor Modulators (SERM)IBA 07/2013 - 02/2009
4	Benzo(a)pyreneIBA 01/2013 - 08/2003
4	Codon (Codons)IBA 06/2006 - 07/2003
3	Aromatase (CYP19)IBA 12/2021 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 11/2020 - 04/2011
3	Menthol FDA Link 12/2019 - 04/2003
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2015
3	DNA AdductsIBA 09/2011 - 09/2010
3	4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- olIBA 03/2010 - 04/2007
3	Estrogen Receptor Modulators (Antiestrogen)IBA 11/2007 - 01/2006
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2010
2	P-2 (P 2)IBA 01/2017 - 04/2003
2	IronIBA 12/2015 - 11/2013
2	Raloxifene Hydrochloride (Evista)FDA Link 09/2015 - 07/2013
2	Tobacco Smoke Pollution (Passive Smoking)IBA 10/2014 - 08/2008
2	Folic Acid (Vitamin M)FDA LinkGeneric 10/2013 - 04/2010
2	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 01/2013 - 11/2007
2	Antipsychotic Agents (Antipsychotics)IBA 08/2012 - 09/2011
2	DNA Repair EnzymesIBA 02/2004 - 07/2002
2	8-Hydroxy-2'-DeoxyguanosineIBA 12/2003 - 07/2002
1	Environmental Pollutants (Pollutants, Environmental)IBA 01/2022
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2022
1	adenovirus receptorIBA 01/2022
1	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2022
1	Cysteine (L-Cysteine)FDA Link 01/2022
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021
1	DNA Transposable Elements (Element, IS)IBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2020
1	3' Untranslated Regions (3' UTR)IBA 01/2020
1	HLA-A Antigens (HLA-A)IBA 01/2020
1	Deoxyribonuclease I (Nickase)IBA 01/2019
1	ElementsIBA 01/2019
1	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA 01/2019
1	UraniumIBA 11/2018
1	RadonIBA 11/2018
1	LigandsIBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	Insulin (Novolin)FDA Link 01/2017
1	LDL CholesterolIBA 01/2017
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2017
1	Hormones (Hormone)IBA 01/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2015
1	Calcitriol Receptors (Calcitriol Receptor)IBA 10/2015
1	Vitamin D FDA LinkGeneric 10/2015
1	Anticarcinogenic AgentsIBA 01/2014
1	CannabinoidsIBA 01/2014
1	Heme (Haem)IBA 11/2013
1	Dietary IronIBA 11/2013

Therapy/Procedure

7	Therapeutics 12/2021 - 10/2007
2	Chemoprevention 10/2020 - 09/2015
1	Self Administration (Administration, Self) 01/2020
1	Drug Therapy (Chemotherapy) 05/2015